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An old issue and a new challenge for nuclear reactor safety
F. D’AURIA
Frontiers in Energy 2021, Volume 15, Issue 4, Pages 854-859 doi: 10.1007/s11708-021-0729-0
Keywords: large break loss of coolant accident (LBLOCA) nuclear reactor safety (NRS) licensing perspectives basis
Progress and perspectives of neural tissue engineering
Xiaosong Gu
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 401-411 doi: 10.1007/s11684-015-0415-x
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.
Keywords: nerve injury tissue engineering nerve grafts
Bioartificial liver devices: Perspectives on the state of the art
Yi-Tao DING, MM, Xiao-Lei SHI, MD
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 15-19 doi: 10.1007/s11684-010-0110-x
Acute liver failure remains a significant cause of morbidity and mortality. Bioartificial liver (BAL) devices have been in development for more than 20 years. Such devices aim to temporarily take over the metabolic and excretory functions of the liver until the patients’ own liver has recovered or a donor liver becomes available for transplant. The important issues include the choice of cell materials and the design of the bioreactor. Ideal BAL cell materials should be of good viability and functionality, easy to access, and exclude immunoreactive and tumorigenic cell materials. Unfortunately, the current cells in use in BAL do not meet these requirements. One of the challenges in BAL development is the improvement of current materials; another key point concerning cell materials is the coculture of different cells. The bioreactor is an important component of BAL, because it determines the viability and function of the hepatocytes within it. From the perspective of bioengineering, a successful and clinically effective bioreactor should mimic the structure of the liver and provide an in vivo-like microenvironment for the growth of hepatocytes, thereby maintaining the cells’ viability and function to the maximum extent. One future trend in the development of the bioreactor is to improve the oxygen supply system. Another direction for future research on bioreactors is the application of biomedical materials. In conclusion, BAL is, in principle, an important therapeutic strategy for patients with acute liver failure, and may also be a bridge to liver transplantation. It requires further research and development, however, before it can enter clinical practice.
Keywords: acute liver failure bioartificial livers hepatocyte bioreactor
Key stakeholders’ perspectives on the ideal partnering culture in construction projects
Gunnar J. LÜHR, Marian G. C. BOSCH-REKVELDT, Mladen RADUJKOVIC
Frontiers of Engineering Management 2022, Volume 9, Issue 2, Pages 312-325 doi: 10.1007/s42524-020-0135-z
Keywords: project culture organisational culture partnering construction culture stakeholder perspectives German
Advances and perspectives in catalysts for liquid-phase oxidation of cyclohexane
Hui LI, Yuanbin SHE, Tao WANG
Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3, Pages 356-368 doi: 10.1007/s11705-012-0903-3
Keywords: cyclohexane liquid-phase oxidation catalysis
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 37-44 doi: 10.1007/s11705-009-0294-2
Keywords: development Polymorphism elucidation controversial relationship
Frontiers of Engineering Management doi: 10.1007/s42524-023-0251-7
Keywords: remanufacturing reverse and closed-loop supply chain circular economy
Min Yu, Zonghai Li
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 509-521 doi: 10.1007/s11684-017-0546-3
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell-based therapies could dominate important roles in the future immunotherapeutic market of HCC.
Keywords: natural killer cell hepatocellular carcinoma immunotherapy
Evolving perspectives on biofuels in the United States
Lisa C. DIRKS, Gary W. DIRKS, Jianguo WU
Frontiers in Energy 2012, Volume 6, Issue 4, Pages 379-393 doi: 10.1007/s11708-012-0213-y
Keywords: renewable energy biofuels energy sustainability
Current perspectives on shoot branching regulation
Cunquan YUAN,Lin XI,Yaping KOU,Yu ZHAO,Liangjun ZHAO
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 38-52 doi: 10.15302/J-FASE-2015053
Keywords: sugar demand apical dominance decapitation shade shoot branching strigolactones
Design and construction of super-long span bridges in China: Review and future perspectives
Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 4, Pages 803-838 doi: 10.1007/s11709-020-0644-1
Keywords: long-span bridges steel box girder design technology construction technology review and future perspectives
Grassland ecology in China: perspectives and challenges
Deli WANG, Ling WANG, Jushan LIU, Hui ZHU, Zhiwei ZHONG
Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 1, Pages 24-43 doi: 10.15302/J-FASE-2018205
Keywords: biodiversity climate change China grazing meadow restoration steppe
New perspectives in free nitrous acid (FNA) uses for sustainable wastewater management
Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11783-024-1786-5
● The historical development of free nitrous acid (FNA) technologies is reviewed.
Keywords: Free nitrous acid Acid-tolerant ammonia oxidizer In situ generation Wastewater management
Air quality improvement in Los Angeles—Perspectives for developing cities
David D. Parrish,Jin Xu,Bart Croes,Min Shao
Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 5, doi: 10.1007/s11783-016-0859-5
Keywords: Air pollution Ozone Particulate matter Control technology
Current situation and future perspectives of European natural gas sector
Vincenzo BIANCO,Federico SCARPA,Luca A. TAGLIAFICO
Frontiers in Energy 2015, Volume 9, Issue 1, Pages 1-6 doi: 10.1007/s11708-014-0340-8
Keywords: natural gas natural gas market oil-linked contracts supply infrastructures gas hubs
Title Author Date Type Operation
Bioartificial liver devices: Perspectives on the state of the art
Yi-Tao DING, MM, Xiao-Lei SHI, MD
Journal Article
Key stakeholders’ perspectives on the ideal partnering culture in construction projects
Gunnar J. LÜHR, Marian G. C. BOSCH-REKVELDT, Mladen RADUJKOVIC
Journal Article
Advances and perspectives in catalysts for liquid-phase oxidation of cyclohexane
Hui LI, Yuanbin SHE, Tao WANG
Journal Article
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
Journal Article
Pricing and production strategies in remanufacturing from the perspectives of supply chain: Review and
Journal Article
Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic
Min Yu, Zonghai Li
Journal Article
Evolving perspectives on biofuels in the United States
Lisa C. DIRKS, Gary W. DIRKS, Jianguo WU
Journal Article
Current perspectives on shoot branching regulation
Cunquan YUAN,Lin XI,Yaping KOU,Yu ZHAO,Liangjun ZHAO
Journal Article
Design and construction of super-long span bridges in China: Review and future perspectives
Journal Article
Grassland ecology in China: perspectives and challenges
Deli WANG, Ling WANG, Jushan LIU, Hui ZHU, Zhiwei ZHONG
Journal Article
New perspectives in free nitrous acid (FNA) uses for sustainable wastewater management
Journal Article
Air quality improvement in Los Angeles—Perspectives for developing cities
David D. Parrish,Jin Xu,Bart Croes,Min Shao
Journal Article